网状内皮组织增殖病病毒免疫抑制状态下禽波氏菌对雏鸡致病性增强

doi:10.11843/j.issn.0366-6964.2017.08.016

Abstract

Abstract:

Bordetella avium (B. avium) can cause a highly contagious disease of upper respiratory tract of poultry and often co-infect with immunosuppressive viruses. In order to study the effect of immunosuppressive state on pathogenicity of B. avium, chick embryos were inoculated with reticuloendotheliosis virus (REV) and infected with B. avium after they were hatched. The body weight, immune organ index, NDV antibody level, B. avium antibody level, the invasion time point of B. avium in different tissues, histopathological changes, and secondary infections of other bacteria were observed respectively under co-infection and simple infection. The results showed that REV caused severe growth inhibition and immunosuppression in chicks which were aggravated by B. avium infection. At the same time, the antibody level of B. avium was interfered. The detection time of B. avium in the liver, heart and kidney of chicks in the immunosuppressive state was 1 d earlier than that in B. avium simple infection group. Chick tracheal mucosa completely fell down and extensive necrosis appeared in liver, heart and other tissues in co-infection group. And the number of secondary infection cases was significantly increased. In conclusion, in the REV immunosuppressive state, the body defense system of chick is destroyed, and the immune response to B. avium decreased. At the same time it provides convenient for the invasion and spread of B. avium in tissues, so the pathogenicity of Bordetella avium increased in the immunosuppressive state induced by REV.

CLC Number:

S852.61

YANG Ping-ping, YUAN Peng, WEI Kai, HU Li-ping, ZHU Rui-liang. Increased Pathogenicity of Bordetella avium in the Immunosuppressive State Induced by Reticuloendotheliosis Virus[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2017, 48(8): 1511-1518.

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Increased Pathogenicity of Bordetella avium in the Immunosuppressive State Induced by Reticuloendotheliosis Virus

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